Have an interesting article in MS-World Results:
Omega-3 fatty acids
Other names: Fish oil, salmon oil, docosahexaenoic acid (DHA), Timnodonsäure = eicosapentaenoic acid (EPA), Docosapentaenoic acid (DPA), alpha-linolenic acid (ALA).
Availability: Pharmacies, Internet ordering, free for sale
General: Omega-3 fatty acids have anti-inflammatory and immune-modulating (= affecting the immune system) and should therefore have a beneficial effect on disease progression in MS.
as omega-3 fatty acids are called fatty acids of all alpha-linolenic acid (ALA) family. ALA is a polyunsaturated fatty acid, which is essential, ie, the body itself can not be produced and supplied to reason with the diet. From it, the body forms the biologically very active fatty acid eicosapentaenoic acid (EPA) and docosahexaenoic acid from (DHA). The amount of converted EPA is only about 10% of the amount of alpha-linolenic acid, which is supplied. Rich in alpha-linolenic acid are particularly certain plant oils such as linseed oil, walnut oil, and rapeseed oil. EPA and DHA are found in fatty cold-water fish such as salmon, herring and mackerel. The eicosapentaenoic acid EPA per 100 g as: g liver 8, Antlantik-Hering 2.04 g, 1.76 g of salt herring, tuna 1.38, sardines in oil, 1.2 g, 0.75 g. Salmon Omega-3 fatty acids are also likely to have a beneficial effect on specific cardiovascular disease and might also be effective against depression.
Status: (Last update: 16.11.07)
• In an animal experiment successfully (1980) [1] •
study analysis shows moderate efficacy (1984) [2]
• Phase (I / II) study shows a trend to effectiveness ( 1989) [3]
• review article emphasizes favorable effects on various inflammatory and autoimmune diseases (2002) [4]
• review article emphasizes lack of evidence of effectiveness (2005) [5]
• Study Analysis (very extensive!) is less conclusive existing studies for MS (2005) [6]
• Phase (I) study shows moderate efficacy (2005) [7]
• Phase (I / II) study planned for depression in MS for 05/2005 [clinical trials]
• review article gives little predictive power of existing studies for MS, current data do not have to little or no effect on disease progression (2007) [8]
• Ongoing studies of MS treatment be determined
assessment of impact: An assessment is not due to the lack of studies currently available.
to assess: ---
dosage and administration: The dosage recommendations in MS vary from 125 mg to 3000 mg EPA / DHA per day. In the determination of personal dose should you pay attention to how much omega-3 fatty acids obtained by one's diet is increasing in, for example in the form of flaxseed oil or fish. Whether it is healthy, the entire amount to be covered by eating fish questionable because fish some environmental toxins (eg, methyl mercury and PCBs) contains. Fish oil supplements are generally free of these substances and should contain more vitamin E or must be taken with vitamin E to protect the delicate Omega-3 fatty acids from oxidation. The currently most common daily dosage is recommended at 1000 mg (= 1 g) EPA / DHA.
Side Effects: Supplementing with fish oil capsules is generally safe and well tolerated. The most common side effects may be a fishy aftertaste (burping) or be sick. Both may try to avoid by taking the capsules during meals or takes any changes the product.
contraindications and interactions: Because omega-3 fatty acids change the flow properties of blood, should people who take blood thinners, discuss the possible use of fish oil capsules with your doctor first. The same goes for diabetics, since fish oils can lead to blood sugar levels and a decrease in insulin secretion into the blood. At the initiation of dosing may lead to a shift of cholesterol, which may be detrimental to heart disease is.
recommendations: a recommendation on the basis of objective data is not currently possible because of the lack of studies. The capture appears but is recommended because of low side effects and better general health effects. When buying supplements you should look for a high proportion (a total of at least 50%) EPA and DHA. "
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